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Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide

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Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide

China Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide supplier
Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide supplier Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide supplier

Large Image :  Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide

Product Details:

Place of Origin: China
Brand Name: Global Chemical
Certification: IOS

Payment & Shipping Terms:

Minimum Order Quantity: 1kit
Price: Negotiable
Packaging Details: as customers request
Delivery Time: 1-2days after receive your deposit
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kits/month
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Detailed Product Description
Name: Jintropin Package: 10vials/box
Formula: C50H69N15O9 Sotre At: Cool Dry Place
Appearance: White Freeze-dried Powder Email: Danielsales@gmail.com
Skype: Live:danielsaleschem

Function of GDF-8

 

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: Muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

GDF-8 / Myostatin Myostatin, Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

 

Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide

 

COA:

Item Specification Result
Appearance White powder Complies
Identification Positive Complies
Assay 99.0% min 99. 3%
Loss on Drying 6.0%max. 4.80%
Mass Balance 95.0~105.0% Complies
Acetate Content (HPIC) 12.0%max. 10.80%
Peptide Content (N%) 80.0%min. 88.00%
Amino Acid Composition ±10% of theoretical Complies
Single Impurity (HPLC) 1.0%max. 0.85%
 

Product Details:

Product Name: GDF-8
Chemical Name: Growth Differentiation Factor 8
Other Names: Myostatin
CAS No.: 901758-09-6
MF: C221H366N72O67S
Appearance: White powder
Dry: Freeze
Purity: >98%

Application

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.


Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

 

Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide

 

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Injectable Growth Hormone GDF-8 Peptides 1mg/vial gdf 8 Myostatin White Peptide
 

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